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Welcome to Hanson Hong Biomedical

Mainly engaged in the research and development and production of protein and stem cells, such as: collagen raw materials and collagen-related products, antigen, antibody raw materials and test reagents, production and application of autologous stem cells, etc.

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Why Choose HANSON HONG BIOMEDICAL?

Founded in 1978 and completed its registration on February 1, 1979, it is mainly engaged in the research and development and production of proteins and stem cells, such as collagen raw materials and collagen-related products, antigens, antibody raw materials and test reagents, and autologous stem cells. Production and its application, etc. Relying on the company's enthusiasm for the biotechnology industry and its dedication to deep-growing self-technologies, under the continuous pursuit of innovative research and development, its products have been widely adopted by medical centers, teaching hospitals, clinics, clinics, pharmacies, and post offices. ). It has passed ISO 9001:2000 and medical equipment GMP certification, and is export-oriented. It has officially obtained the certification of the Japanese Ministry of Health and Welfare. It is exported to several countries in Asia and Europe under its own brand. The product quality and service have won the trust and praise of customers.

About us

About Hanson Hong

Company purpose: product innovation, training talents. Take full responsibility for the users who purchase the company's products.

Biomedical

Mainly engaged in the research and development and production of protein and stem cells, such as: collagen raw materials and collagen-related products, antigen, antibody raw materials and test reagents, production and application of autologous stem cells, etc.

Cooperation

Thank you for your love and support to this website! If you want to discuss cooperation plans with us, or if you have any questions about the products or services provided by this site, you are welcome to contact us in the following ways, and we will respond to your questions wholeheartedly.

NEWS

Collagen Master Video

Collagen Master Video-

YouTube https://www.youtube.com/channel/UCb1QQRdNLwk8irFiXpmcZUg

FB https://www.facebook.com/41collagen/posts/1797905437032631

 

 


Any questions, please call 886 2-27883621

It’s so hot! Is your collagen dead?

Your skin care products should be upgraded

 

 

The skin care products you use every night are used for basic maintenance. It is not enough, because it can’t shrink the pores and lift the skin. After 10, 20, 30 years, it is still the same old. It cannot prevent skin aging. For your beautiful face, it is time to upgrade your daily basic skin care products to daily basic repair products. Let 41℃ soluble collagen automatically upgrade you to professional repair products. 41℃ soluble collagen can Go deep into the skin and take care of your skin every day.

Go to the official website of 41℃ Collagen

 

What are horror AGEs? Eat this way to prevent a large amount of accumulation (China Times Newsletter)

What are horror AGEs? Eat this way to prevent a large amount of accumulation (China Times Newsletter)

https://www.chinatimes.com/realtimenews/20191011002160-260405


Olive oil has far fewer AGEs than other vegetable oils. Several components, such as vitamin E and flavonoids, have excellent antioxidant and anti-inflammatory effects. (Image source: Pixabay)

Visualine II® Dual Occult Blood FaecoCheck Test

Visualine II® Dual Occult Blood FaecoCheck Test

A monoclonal antibody immunochromatographic method that directly detects human hemoglobin in the stool, an immunoassay/chemical dual-effect test piece
fecal occult blood reaction-colorectal cancer screening reagent (Patented and Pending)

Visualine® Faecocheck The test piece is a flow chromatographic monoclonal antibody immunoassay method, which is used in stool occult blood reaction-colorectal cancer screening test to detect the presence of human hemoglobin (Human Hb) in stool samples. In addition to simple operation, it also provides a quick visual observation result. FaecoCheck test is a double-effect test piece that combines OB-immune method and OB-chemical method in one. Using the method of increasing the concentration of the tested sample, you can watch the OB-immune method (mainly used as the lower gastrointestinal tract) on the same test piece. Screening) and OB-chemical method (mainly as a screening test for the upper gastrointestinal tract)。HansonTM Visualine®FaecoCheck The test piece is highly specific to human hemoglobin. It has been proved by in vitro tests that it does not interact with animal hemoglobin and peroxidase (in vegetables) and MyoglobinCross-reaction occurs. It provides two methods for applying samples at the same time. After applying the sample for 10 minutes, it can be transported to the test room immediately or within 14 days, and the coloring agent is dripped and the result is directly observed.

Collagen Stay away from mad cow disease, avian collagen Skincare - Full effect maintenance, just two bottles

41°C Avian Soluble Collagen

41℃ Avian Soluble Collagen

Hengshengxing Biotechnology Co., Ltd. has officially invested in the research and development of collagen since 1992. After eight years of countless failures and efforts, the R&D team finally successfully extracted 41℃ soluble collagen from birds in 1999, and formally invested it. Mass production, because the purity of the extracted is at least 98%, the quality is still beyond the international level, and it is a widely used and high-quality medical-grade biomaterial. In the same year, the board of directors made a formal decision to give priority to the development of repair-grade cosmetics/care products suitable for aging skin regarding the application of 41°C soluble collagen. In this regard, the R&D team once again quickly invested in the research and development of the first set of skin care formulas, with the greatest goal of repairing effects and not causing skin burden. After more than one year of experimental results and data accumulation, the skin was completed on the basis of medical theory. The absorption (permeability) test determined the formula of the versatile 41℃ medical-grade repair and maintenance product. It was officially launched in December 2000, a biotechnology product specifically aimed at repairing and maintaining aging skin, named 41°C soluble collagen. The birth of this formula focuses on immediate repair effects. It uses the concept of immediate effectiveness. It is a set of repair combinations that are based on biotechnology and specifically researched and developed for aging skin. It breaks the use of chemical skin care products. The brand's traditional concept of "wiping Ping An", 41℃ is effective for whitening, rough skin, enlarged pores, wrinkles, sagging skin, scars, stretch marks, cavities, acne and acne scars, laser or dermabrasion. Damaged skin can immediately let you see the effect, it is a set of skin care products most suitable for skin.

For more information, please go to the 41℃ soluble collagen website:http://www.collagen.com.tw/

A series of courses will be held from now on

Will be2nd Floor, No. 41-1, Yitong Street, Taipei City(Yitong Gallery) Holds a series of courses。

Time:

  1. Held at 1 p.m. every Thursday

  2. Held irregularly at other times

  3. The time and content of the course are subject to the announcement on the company's website

Contact phone:02-27883621

 

Use automatic biochemical analyzer to determine Hanson AGEs Immunoassay,Get quantitative values

Use automatic biochemical analyzer to determine Hanson AGEs Immunoassay,Get quantitative values

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Products

Advanced Glycosylation End Products(AGEs) test(Invention Patent of the Republic of China)

Hanson® Advanced Glycosylation End Products (AGEs) Immunoassay,
50ml/kit (suitable for autoanalyzer and manual operation)
Advanced Glycosylation End Products (AGEs) are the final products formed by the Maillard reaction of sugars and proteins. When the tissues in the body are in a high-sugar (diabetic hyperglycemia) environment, the excess carbohydrates will combine with the proteins in the tissues (blood) to form the final product of AGEs through the Mener reaction. Past research results have shown that AGEs can cause cells in the body to produce harmful free radicals and release substances that induce allergic reactions, leading to inflammation and causing tissue or organ disease. It is currently considered to be the main factor in the production of diabetes complications. Therefore, detecting the content of AGEs in the body is currently an important indicator for clinically monitoring the occurrence, progression and treatment of diabetic complications. In addition, for smokers, AGEs will appear in the blood after a few hours after the smoke and blood contact. AGEs are also commonly found in sugar pickles and high-temperature cooked foods, such as grilled and fried foods.
HbA1c is an intermediate product of the Mena reaction process, which is mainly used to monitor the quality of blood glucose control in diabetic patients in the past four months as a reference indicator, and cannot be used as an indicator of complications.
The biggest feature of the AGEs immunoassay reagent developed by Hengshengxing Biotechnology is that the detected serum AGEs content is given a standardized value. We use serum standards to develop a stable standard curve, Hanson® AGEs immunoassay The reagent can quantify the content of AGEs in serum to achieve the purpose of early diagnosis and early treatment.
Common complications caused by diabetes
Drugs (components) for the treatment of diabetes complications (lowering blood AGEs)
Benfotiamine (fat-soluble B1) literature has shown that it can prevent the formation of AGEs in the body and become a candidate for the treatment of diabetic complications. This ingredient has been approved by the US FDA and is under review.
Finding a drug to treat diabetes complications (reducing AGEs) is a greater business opportunity than hypoglycemic drugs. It is the most popular thing for major pharmaceutical companies. Currently, the drugs in clinical trials are known to be Aminoguanidine, ACE, and ALT. , Benfotiamine, ARB, Metformin...etc. In addition, Tomato paste (tomato paste), Resveratrol (resveratrol), inositol (inositol), Ginger (ginger), Cinnamon (cinnamon) - and other ingredients have been reported in articles, which have excellent effects on reducing AGEs.
(For further information on AGEs test and related medical literature, please contact 0800-000-041)
Cat. No. English name Chinese name Packing
AGE-200 Hanson® Advanced Glycosylation 
End Products (AGEs) Immunoassay,
(suitable for autoanalyzer and manual operat ion)
Hanson® Final glycosylated protein immunoassay reagent
(Republic of China invention patent)
50ml/kit

Published medical literature

Autologous P-Stem Cell (Patented)(Invention Patent of the Republic of China利)

Customize autologous P-Stem Cell

The standardized of stem Cell treatment

What is Minimum Effective Dose for stem cell treatment?
Ans: 200 million per time.
2 million stem cell per kg(body weight). 100kg human body = 200 million stem cell per time.

How many stem cell that you can collect from bone marrow, peripheral blood or fatty tissue?
Ans: several million stem cell only.



The picture above shows that the company has cultivated different types of nerve cells in vitro


You have many stem cells in your own bone marrow and blood------------
Your knee joints are so worn that you can’t walk. Why can’t the stem cells in your body repair your joints and can’t save it?

You have a stroke. Why can’t your own body’s stem cells save you and keep you paralyzed?

You have a myocardial infarction, why your own stem cells can’t restore your blocked cardiovascular system to normal?

How many stem cells are there in your entire bone marrow? How many stem cells (bone + blood + tissue) are there in your entire body?

Standardization of stem cell therapy

What is the minimum effective dose of stem cells?
Answer: The minimum effective dose of stem cells is 1 kg 2 million. A human with 100 kg body weight needs 200 million (1 kg 2 million X 100 kg = 200 million stem cells).

Multifunctional P-autologous stem cells

(a bag of blood),(Help you make 200 million autologous stem cells in just 2 days). (2 million pcs/kg)

Invention patents: the Republic of China, China, Australia, the United States and other countries.

 

 。

 

 

(Counterfeiting must be investigated)

related services related to autologous stem cells, patent authorization, technical cooperation, whole plant output, Contact Mr. Liu- 0910215561

Let us work together to create the future

The current predicament of the stem cell industry?
1. Repulsive effect
The chance of someone else’s stem cell pairing with you is small, and the success rate is about 1 in 100,000 to 1 in 1 million, so it is not easy to obtain.

2. Insufficient number of stem cells
At present, the total number of autologous stem cells that can be collected is about several million, which is still a long way from the number of 200 million. Due to insufficient quantity, the effect remains to be seen.

3. A course of treatment requires 5 consecutive injections. How to supply it?
It is not easy to obtain a injection of autologous stem cells (although the number is insufficient). If a course of treatment requires 5 injections. How to supply?

 

41°C Avian Soluble Collagen

Avian Collagen(Avian Soluble Collagen),Supply of medical-grade raw materials with a purity of at least 99.9%. It is a widely used and high-quality medical-grade biomedical material(biomaterial)。

41℃Avian soluble collagen

41℃ Avian Soluble Collagen

(This is a bottle of soluble collagen raw material with a purity of 99.9% extracted from the factory)

Hengshengxing Biotechnology Co., Ltd. has officially invested in collagen research and development since 1992. After eight years of countless failures and efforts, the R&D team finally successfully extracted 41℃ soluble collagen from birds in 1999, and formally invested it. Mass production, because the extracted purity is at least 99%, and the quality is still beyond the international level, it is a widely used and high-quality medical-grade biomaterial. In the same year, the board of directors made a formal decision to give priority to the development of repair-grade cosmetics/care products suitable for aging skin regarding the application of 41°C soluble collagen. In this regard, the R&D team once again quickly invested in the research and development of the first set of skin care formulas, with the greatest goal of repairing effects and not causing skin burden. After more than one year of experimental results and data accumulation, the skin was completed on the basis of medical theory. The absorption (permeability) test determined the formula of the versatile 41℃ medical-grade repair and maintenance product. It was officially launched in December 2000, a biotechnology product specifically aimed at repairing and maintaining aging skin, named 41°C soluble collagen. The birth of this formula focuses on immediate repair effects. It uses the concept of immediate effectiveness. It is a set of repair combinations developed specifically for aging skin based on biotechnology. It breaks the brand of chemical skin care products. The traditional concept of "wiping peace", 41℃ is suitable for skin whitening, rough skin, enlarged pores, wrinkles, sagging skin, scars, stretch marks, pits, acne and acne scars, damaged skin after laser or dermabrasion , Can let you see the effect immediately, it is a set of skin care products most suitable for skin。

For more information, please go to the 41℃ soluble collagen website:http://www.collagen.com.tw/

OEM Supply Or the whole factory output, please contact Mr. Liu at 02-277883621

The comparison of current stem cell

(Autologous P-Stem Cell)

The comparison of current stem cell

 

 

Visualine II® Dual Occult Blood FaecoCheck Test

A monoclonal antibody immunochromatographic method for direct detection of human hemoglobin in the stool, a dual-effect test piece of immunoassay/chemical method
Fecal occult blood reaction-colorectal cancer screening reagent (Patented and Pending)

To

Weisuling® Faecocheck test piece is a flow chromatographic monoclonal antibody immunoassay method, which is used for fecal occult blood reaction- Colorectal cancer screening test is used to detect the presence of human hemoglobin (Human Hb) in stool samples. In addition to its simple operation , It also provides a quick visual observation result. FaecoCheck test is a combination of OB-immunoassay and OB-chemical method The dual-effect all-in-one test piece in one body, using the method of increasing the concentration of the tested sample, on the same test piece, you can watch the OB-immunization method (mainly used as a lower gastrointestinal tract screening) and OB-Chemical method (mainly used for upper gastrointestinal screening) double-effect result. HansonTM FaecoCheck ® FaecoCheck test strip has high specificity for human hemoglobin It has been proved by in vitro tests that it does not cross-react with animal heme, peroxidase (in vegetables) and Myoglobin. It also provides two methods for applying samples, 10 minutes after applying the sample , Can be transported to the test room immediately or within 14 days, drop the coloring agent, and directly observe the results.

Knowledge

Deadly Inflammatory Substances-Ultimate Glycosylated Proteins (AGEs)-Diet

The deadly inflammatory substance-the final glycosylated protein (AGEs)-Diet articles
Cooking food at low temperature will make you live healthier and live longer

Care健康志  2011/04  p28~p29        Text: Liu Yongxiang, General Manager of Hengshengxing Biotechnology

Finally, glycosylated proteins (AGEs), a kind of deadly substance that can cause inflammation in blood vessels, which can lead to organ diseases. Common reasons for the rise of AGEs in the body are diabetes, smoking, and ingestion of high-temperature fried, grilled, and pickled foods.

High temperature cooking is the most serious culprit that endangers health

According to a report by CBC News, according to a new study, cooking food under high temperature conditions increases the chance of a potentially toxic substance in the food. Researchers say that the formation of this toxic substance is Using high-temperature frying, grilling, or microwave cooking of sugars, proteins and fats, the toxic substances are called advanced glycation end products or AGEs, which can cause inflammation-related diseases when they appear in the body after ingestion.

Dr. Helen Vlas sara, (Mount Sinai School of Medicine in New York), a diabetes researcher, presided over the study. She said that the vascular damage that diabetes patients are particularly sensitive to is caused by AGEs.

Eugene Barret, professor of medicine at the University of Virginia and president of the American Diabetes Association, said that the conclusion of the study, inhibiting the production of final glycosylated proteins (AGEs) will contribute to the health of diabetic patients.

Dr. Vlassara and her colleagues studied 24 diabetic patients for six weeks. They all got exactly the same food, including chicken, fish and meat, but the food was cooked in different ways. Half of the patients ate grilled tuna, while the others ate boiled tuna. Researchers have found that food cooked at low temperatures, such as boiled and steamed, contains less final glycated protein (AGEs). The researchers wrote that a group of people who ate grilled tuna with high final glycated protein (AGEs) had higher levels of final glycated protein (AGEs) in their blood. Another group ate boiled tuna, and the final glycated protein (AGEs) content in the blood was reduced by 33-40%.

Dr. Vlassara said that the inflammatory response produced by AGEs has been linked to complications of heart disease and diabetes, such as arteriosclerosis, cataracts, blindness, nerve damage and kidney damage. Dr. Vlassara said that in animals In the experiment, a diet low in AGEs also helped prevent Type I diabetes.

The key to reducing AGEs is that the food is cooked in a very short time under high temperature environment. Meat should be cooked or steamed in the minimum required time. Fried meat should be very thin, less oil, and quickly cooked. The above is a report by CBC News November 14, 2002.

The high-temperature cooking mentioned here results in the production of final glycated protein (AGEs) in the food, which is the same thing as the AGEs produced in the body of diabetes, and the same thing as the AGEs produced in the body after smoking. They are all the deadly substances that will cause inflammation in your body, which in turn will cause you to produce organ diseases.

It takes several weeks to several months for people with diabetes to produce AGEs in their bodies. It takes several hours to produce AGEs in the body after smoking, and it takes several minutes to several minutes to produce AGEs in high-temperature cooking foods. You see, if you eat grilled eel, fried pork ribs, pickled yellow radish every day, there are high levels of toxic AGEs in it, which will make you suffer from chronic inflammation for a long time and make your organs sick earlier.

Change your eating habits, eat less high-temperature fried, grilled, and pickled foods, eat more steamed, boiled, vegetables and fruits, and cook foods at low temperatures, which will make you live healthier and live longer. .

Reference:

  1. Vlassara H. "Advanced glycation in health and disease: role of modern environment. ," Ann N Y Acad Sci 2005; 1043: 452-60
  2. JAIME URIBARRI, Restriction of Dietary Glycotoxins Reduces Excessive Advanced Glycation End Products in Renal Failure PatientsJ Am Soc Nephrol 14: 728–731, 2003
  3. Smit AJ, et al. " Advanced glycation endproducts in chronic heart failure," Ann NY Acad Sci 2008; 1126: 225-30
  4. Weijing Cai,Reduced Oxidant Stress and Extended Lifespan in Mice Exposed to a Low Glycotoxin Diet, The American Journal of Pathology, Vol. 170, No. 6, June 2007
  5. Tokita Y, et al. " Fructose ingestion enhances atherosclerosis and deposition of advanced glycated end-products in cholesterol-fed rabbits," J Atheroscler Thromb 2005; 12(5): 260-67
  6. M. KRAJ OVI OV-KUDL KOV, Advanced Glycation End Products and Nutrition, Physiol. Res. 51: 313-316, 2002
  7. Danesh, J, et al. "Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses," BMJ 2000; 321: 199-204
  8. A. Foerster and T. Henle, Glycation in food and metabolic transit of dietary AGEs (advanced glycation end-products): studies on the urinary excretion of pyrraline, Biochem. Soc. Trans. (2003) 31, (1383–1385)
  9. Goldberg T, Advanced glycoxidation end products in commonly consumed foods, J Am Diet Assoc. 2004 Aug;104(8):1287-91.
  10. Jung UJ, et al. "n-3 Fatty acids and cardiovascular disease: mechanisms underlying beneficial effects," Am J Clin Nutr 2008; 87(6): 2003S-9S
  11. Plaisance EP and Grandjean PW, "Physical activity and high-sensitivity C-reactive protein," Sports Med 2006; 36(5): 443-58


Olive oil has far fewer AGEs than other vegetable oils. Several components, such as vitamin E and flavonoids, have excellent antioxidant and anti-inflammatory effects. (Image source: Pixabay)

Deadly Substances Causing Diabetes Complications-Ultimate Glycosylated Proteins (AGEs)-Smoking

Care健康志  2011/01  p46~p47        Text: Liu Yongxiang, General Manager of Hengshengxing Biotechnology

At noon on last Saturday’s holiday, I was preparing to go out for lunch with my family. The phone rang, and Mr. A’s voice "I am in the emergency room" came out. After a moment, the sound was normal. After asking about the hospital, he rushed inside. In the emergency room of Lake Medical Center, the doctor in the emergency room said that Mr. A’s heart stopped beating, and he was rescued with electrodes just now. My heart was SOS. Mr. A was lying on the bed and looked at me and said, chest tightness, back pain, and breathing difficulties. His daughter Added that less than 20 minutes after arriving in the emergency room, I was in a coma. It was a myocardial infarction. I urgently received a cardiac catheterization and installed a stent. After one day of observation in the intensive care unit, he was transferred to the general ward. In the ward, Mr. A was full of breath. I said, fortunately, I fell in the emergency room. If I fell at home, it would be dangerous. I smiled and did not answer. Mr. A is a martial artist. He is healthy, his blood test and blood pressure are all normal, but he smokes cigarettes. It is very big, with a smoking age of more than 35 years, I suddenly thought of the final glycated protein (AGEs).

In diabetic patients, under high blood sugar conditions, glucose in the blood will naturally combine with protein, lipid, and nucleic acid in the blood through the Mener reaction ( Maillard Reaction), will produce a large amount of Advanced Glycosylation End product (AGEs) in the blood. This final Glycosylation End product (AGEs) will cause inflammation, which is the killer of the complications of diabetes. The final glycated protein (AGEs) in the blood will be combined with the final glycated protein donor (AGE-Receptor, RAGE) on the vascular endothelial cells, and then combined with HMGB1 (amphoterin) will immediately trigger an acute inflammatory response. Complications of cardiovascular disease (hypertension, atherosclerosis), kidney disease (dialysis), eye disease (cataract), peripheral nerve injury, etc. These are typical complications of diabetes.

Huebschmann et al.’s 2006 medical paper counted 100 AGEs-positive patients, of which about 20-30% were not diabetic patients. These 20-30% of the patients had high AGEs concentration (positive The source of reaction) is from smoking and eating foods with high AGEs content.

Smoking does cause an increase in blood AGEs. A medical paper published by CERAMI et al. in 1997 showed that both tobacco extracts and smoking smoke extracts contain glycotoxin, which is a kind of High reactive glycation products can quickly combine with proteins to produce AGEs and also induce gene mutations.

Hyperglycemia in the blood of diabetic patients takes about several weeks to several months to form AGEs in the body; glycotoxins in tobacco are inhaled in large quantities into the alveoli, and then absorbed into the blood and combined with proteins , It only takes a few hours to quickly produce AGEs. CERAMI's medical papers, one of the experiments is to detect the comparison of AGEs in the blood of smokers and non-smokers. The experimental results show that the blood AGEs content of smokers (210.6 ± 51 AGE unit/ml) is higher than that of non-smokers (161.6 ±). ; 53 AGE unit/ml) is 30% higher.

The large amount of AGEs produced by smoking will cause inflammation, which will develop into atherosclerosis in the long run. Medical papers published by predecessors revealed that the number one fatal disease caused by smoking is myocardial infarction, and other smoking-related diseases include peripheral vascular diseases, cerebrovascular diseases and other diseases.

During the health check, it is necessary to check whether the concentration of AGEs in the blood is normal. Patients who are positive for AGEs will be screened and given appropriate treatment for lowering AGEs, or their lifestyle habits (quit smoking or diet) will be adjusted , Will be able to effectively prevent the occurrence of cardiovascular and other diseases.

Reference:

  1. CARLA CERAMI etl Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 13915–13920, December 1997, Medical Sciences
  2. Robbins, S. L., Kumar, V. & Cotran, R. S. (1994) in Pathological Basis of Disease (Saunders, Philadelphia), 5th Ed., pp. 379–430.
  3. Shah, P. K. & Helfant, R. H. (1988) Chest 94, 449–452.
  4. Sherman, C. B. (1991) Clin. Chest Med. 12, 643.
  5. Vlassara, H., Fuh, H., Makita, Z., Krungkrai, S. & Cerami, A. (1992) Proc. Natl. Acad. Sci. USA 89, 12043–12047.
  6. Brownlee, M., Cerami, A. & Vlassara, H. (1988) N. Engl. J. Med. 318, 1315–1321.
  7. Bucala, R., Model, P., Russel, M. & Cerami, A. (1985) Proc. Natl. Acad. Sci. USA 82, 1670–1674.
  8. Lee, A. T. & Cerami, A. (1987) Mutat. Res. 179, 151–158.
  9. Lee, A. T. & Cerami, A. (1987) Proc. Natl. Acad. Sci. USA 84, 8311–8314.
  10. Lee, A. T. & Cerami, A. (1990) Mutat. Res. 238, 185–191.
  11. Bucala, R., Makita, Z., Koschinsky, T., Cerami, A.&Vlassara, H. (1993) Proc. Natl. Acad. Sci. USA 90, 6434–6438.
  12. Bucala, R. & Cerami, A. (1996) in The Maillard Reaction: Consequences for the Chemical and Life Sciences, ed. Ikan, R. (Wiley, Philadelphia), pp. 161–181.

(Latest edition) The killer of diabetes complications-AGEs (Final Glycosylated Protein)

Causing complications of diabetesMurder– AGEs (Final Glycosylated Protein)

 

Diabetes

The so-called diabetes means that the concentration of blood glucose (glucose) is too high to exceed the standard value. After the doctor confirms that you are diabetic, the doctor will use blood sugar lowering (insulin) drugs to try to control your blood sugar within the normal value. At the same time, the doctor will also test your glycosylated hemoglobin (HbA1c) to see if your blood sugar control is good or not in the past few months, or test Glycated Alibumin (GA) to see the blood sugar control status in the past 2 weeks. The reminder you should avoid food, take medicine on time, and control blood sugar well.

 

The killer of diabetes complications

Although you worked hard to cooperate, with the passage of time, it was accompanied by the emergence of complications, and it seemed that no one was spared. You have high blood pressure, proteinuria, blurred vision, more serious cases, such as cardiovascular disease (arteriosclerosis, myocardial infarction, stroke), kidney failure (uremia), dialysis, cataracts, peripheral neuropathy, etc. Diabetic patients seem to have no Fortunately, it's just a difference in speed and severity. Thanks to science and technology and nearly 40 years of research efforts, the culprit responsible for the complications of diabetes has been found, that is, AGEs (ultimate glycosylated proteins) that are abnormally elevated in the blood.

 

Final glycated eggFormation of white and Mena reaction

The mystery of the complications of diabetes has finally been solved by scientists. The final glycated protein (Advanced Glycosylation End Product, AGEs) is the deadly killer of the complications of diabetes. The final glycated protein (AGEs or AGE) is also called glycation. End product or advanced glycation end product. In diabetic patients, when the blood is at a high concentration of glucose, the carbonyl group of glucose in the blood binds to the amino group of arginine or lysine on protein, nucleic acid or fat, and directly undergoes glycation reaction. The entire saccharification reaction process is also called Maillard Reaction (Maillard Reaction), and the final products of this reaction are called final glycated proteins (AGEs).

 

Final glycated proteinReaction with inflammation

When the final glycated protein (AGEs) appears in the blood, the final glycated protein (AGEs) will bind to the AGEs Receptor (final glycated protein receptor) on vascular endothelial cells and produce superoxide radicals, which are activated AGEs Receptor combined with HMGB1 (High Mobility Group Box-1) and S-100 (11) will directly induce an inflammatory response, which will lead to systemic cardiovascular disease, kidney disease, cataract, Peripheral neuropathy is currently considered to be one of the main factors of diabetic complications(3、16,17). Cells with AGE receptors in humans include Endothelial Cell blood vessel, smooth mucle cell blood vessel, Podocyte foot cell (kidney), Astrocyte/Microglia astrocyte/nerve, Monocyte /Macrophage(immune system)(12). Podocytes located in the glomerulus are specifically responsible for filtering. When free AGEs combine with the AGE receptors on the podocyte membranes, an inflammatory response is generated, which makes the podocytes ineffective in filtering and allows proteins to escape. The microalbumine/urine protein is positive (13); the first layer of blood vessels is endothelial cells. When the second layer of smooth muscle cells combine with AGE to produce an inflammatory response, resulting in smooth muscle cell proliferation, Homocysteine ​​will increase. , The proliferation of vascular smooth muscle cells causes the vascular wall to bulge to form plaques (Plaque)(14); when AGE attacks the elastin of the blood vessels, it will harden and lose its elasticity, causing blood pressure to rise; the literature points out that AGE causes Vascular lesions, atrophy and necrosis are one of the causes of male sexual insufficiency (19, 20). Evidence shows that the brain of Alzheimer’s disease deposits a large amount of amyloid (starch-like substance), and AGE is its precursor. Body ( Precursor)(18), AGE causes cataracts, and also attacks Cornea, Vitreous, and Retina to cause related lesions(15) , ------ -.

 

Final glycosylated proteinExcretion

AGEs are mainly excreted through the kidneys. AGEs can be bound by the clearance receptors of specific cells, decomposed into amino acids and small molecule peptides through catalysis, and then excreted by the kidneys. Most kidney cells include endothelial cells, renal tubular cells, glomerular cells, and pseudopodia Blood cells all contain the AGE clearance receptor, including AGE-R1, AGE-R2, and AGE-R1. -R3), and the phagocytic cell clearance receptor (MSR) includes SR-AII, SR-BI and CD-36. The literature pointed out that when the kidney starts dialysis, the concentration of AGE in the blood will increase by 50 times.

 

What are the reasons for the increase in the concentration of final glycated protein (AGEs) in the human body?

1) Hyperglycemia in the blood of diabetic patients is the main cause of the increase in AGEs in the body.

2) Ingested from food, for example: drinking foods high in AGEs, including fried, grilled and pickled foods.

3) Medical literature also shows that smoking is another important source of increasing AGEs in the body.

 

Final glycated protein detection and monitoring

As the final glycated protein (AGEs) is the killer of the complications of diabetes, it has become an important task to detect the presence and concentration of AGEs in the blood. Early detection of abnormal rise of AGEs in the blood is important. It allows you to detect the inflammatory response of blood vessels caused by AGEs at the earliest possible time, so as to achieve the purpose of early detection and early treatment. The monitoring of the final glycated protein (AGEs) concentration can be used as a therapeutic indicator. Therefore, detecting the concentration of AGEs in the blood is currently an important indicator for monitoring the complications of diabetes.

 

Using drugs or active ingredients to eliminate AGEs in the blooddiabeticsThe most direct and effective way to block inflammation and complications is the most direct and effective way to block inflammatory reactions and complications.

The effective ingredients or drugs that reduce the concentration of AGEs in the blood? and the principle of action?

1.) Effective ingredients or drugs to prevent the formation of AGEs: ALT946, LR90, OPB9195, PARP inhibitor, B6 (Pyridoxamine),    Aminoguanidine, Benfotiamine, AR inhibitors, etc.

2.) Effective ingredients or drugs that destroy AGEs crosslink: PTB (N-phenacylthiazolium bromide), ALT711, etc.

3.) Anti-hypertensive drugs (can also lower AGEs):  ARB, ACE inhibitor, etc. 4.)  AGEs binding agent: Soluble RAGE, Lysozyme, etc.

5.) Antioxidants: Green Tea, Vit. E, Vit. C, etc. 6.) Oral hypoglycemic drugs (can also lower AGEs): Metformin, Pioglitazone.

 

Other natural ingredients that have been published in the literature that can eliminate/block the formation of AGEsinclude:

Tomato paste (tomato paste), Resveratrol (resveratrol), inositol (inositol), Carnosine (carnosine), Curcumin (curcumin), Rosemary (rosemary), Alpha-lipoic acid (α- Lipoic acid), Flavonoids luteolin (flavonoid compound luteolin), rutin (rutin), quercetin (quercetin), kaempferol (kaempferol), Ginger (ginger), Cinnamon (cinnamon), Cumin (cumin) .

 

As the final glycated protein (AGEs) in the formation of diabetes complications and the mechanism of complication, it has been confirmed in experiments by researchers around the world in the past 30 years that it can prevent the formation of AGEs and eliminate AGEs in the blood. The ingredients (drugs) of the drug have become a matter of concern to everyone at once. Through the research of scientists and the input of pharmaceutical companies, the drugs or effective ingredients related to the elimination (reduction) of the final glycated protein (AGEs) have been discovered one after another, and some are in progress. In clinical human trials, some of the existing drugs have the ability to lower the final glycated protein (AGEs), some have been sold in the market, and some are natural ingredients. It is worth mentioning that Benfortiamine (B1 The fourth phase of the clinical trial of the derivative) has ended with excellent results. It is waiting for the approval of the US FDA to become the first AGE-lowering drug candidate of the US FDA. The Hanson AGEs Test test reagent produced by Hengshengxing Biotechnology Co., Ltd. It can measure the concentration of AGEs in the patient's blood at any time. It is an important monitoring tool. In addition, the oral hypoglycemic drugs Metformin, Pioglitazone, and Atorvastatin approved by the FDA have the ability to lower AGEs. They are all great experimental results and messages. All of these will enable medical staff to be more capable of caring for and educating people with diabetes, thereby improving the quality of life and life expectancy of people with diabetes. Let us work together.

 

Reference material:

1. Kidney International(1999) 55, 389–399     2. Current Alzheimer Research, Volume 1, Number 1, February 2004 , pp. 39-46(8)

3. Diabetes Care 29:1420-1432, 2006         4. Glycobiology vol. 15 no. 7 pp. 16R–28R, 2005

5. Cardiovascular Diabetology 2008, 7:29      6. Cardiovascular Diabetology 2002, 1:1

7. Circulation Research. 2004;95:233-238       8. Am J Hypertens. 2004 Dec;17(12 Pt 2):31S-38S

9. Nature 414, 813-820 (13 December 2001)   10. Clin Biochem Rev. 2005 November; 26(4): 123–134.

11. Kidney International (1999) 56, S54–S56    11. Biochim Biophys Acta. 2010 Jan-Feb;1799(1-2):164-70  

12. Cell Mol Biol 1998, 44:1013-1023          13. Nephrol Dial Transplant (2008) 23: 2179–2191

14. Exp Clin Cardiol Vol 7 No 1 Spring (2002)   15. Br J Ophthalmol 2001;85:746–753

16. Lab Invest 1994;70:138–51.                17. Martin Dunitz, 1999:67–92

18. J Neural Transm 1998;105:439–61.          19. World J Urol 1995;13:369–75

20. Urology 1997;50:1016–26. 

The comparison of current stem cell

(Autologous P-Stem Cell)

The comparison of current stem cell

 

 

AGEs Vs HbA1c

AGEs Vs HbA1c

Ideal Diabetes Complications Treatment Method-Comparison of Diabetes and Its Complications Treatment

Comparison table of traditional diabetes treatment and ideal diabetes B6 treatment

Computer information of the final glycated protein (AGEs test) reagent

Thank you for your support for Hengshengxing Biotechnology in the past few years. Hanson AGEs tests have been able to directly access the automatic biochemical analyzer and obtain the experimental results in 10 minutes. This quantitative value can be used as a treatment indicator under long-term tracking. Currently available biochemical analyzers include Hitachi, Toshiba, Olympus and Beckman models. For related information, please contact the sales department, thank you. Thank you for your support for Hengshengxing Biotechnology in the past few years. Hanson AGEs tests have been able to directly access the automatic biochemical analyzer and obtain the experimental results in 10 minutes. This quantitative value can be used as a treatment indicator under long-term tracking. Currently available biochemical analyzers include Hitachi, Toshiba, Olympus and Beckman models. For related information, please contact the sales department, thank you.

The relationship between Advanced Glycosylation End Product (AGEs) and dialysis patients

Text: Liu Yongxiang, General Manager of Hengshengxing Biotechnology There are three sources of increased AGEs in the blood. 1. Diabetes patients 2. Smokers 3. People who eat fried and grilled foods. The final glycated protein concentration in the blood of normal people is very low. The long-term abnormal increase in the concentration of AGEs in the blood will immediately cause systemic vascular inflammation, and the blood vessels will die for a long time, leading to organ diseases, including atherosclerosis, hypertension, myocardial infarction, stroke, kidney disease (nephritis), kidney Failure (dialysis), cataracts, retinopathy, peripheral nerve damage, etc., no diabetic patient can escape this spell before. The AGEs in the blood will be excreted through the action of the kidneys to maintain the health of the body. For dialysis patients, the function of the kidneys to excrete AGEs will be greatly reduced, or even lose this function, which means that the blood of diabetic dialysis patients The concentration of AGEs is extremely high, and the progress of its complications is rapid. The final glycated protein (AGEs) can be washed out by hemodialysis or peritoneal dialysis. This is very important for dialysis patients. It is determined that AGEs in the blood of dialysis patients are washed out, which will directly reduce/slow the harm of complications, and then Extend the life span of dialysis patients.

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